Immunosuppression after Liver Transplantation
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چکیده
منابع مشابه
What every pediatrician should know about liver transplantation
Liver transplantation is the treatment of choice for children with end-stage liver disease. Improvement in outcomes (allograft and patient survival) has led to widespread use of pediatric LT worldwide. This success is due to improvement in patient selection, transplant surgery, anesthesia/postoperative care and immunosuppression management. This review will focus on different aspects of LT whi...
متن کاملLong-term Management of Immunosuppression After Pediatric Liver Transplantation: Is Minimization or Withdrawal Desirable and/or Possible?
Purpose of Review—The aim of this review is to review available data regarding the risks and benefits of indefinite immunosuppression versus attempted immunosuppression withdrawal for children who have undergone liver transplantation. Recent Findings—Emerging data suggest that conventional immunosuppression practices may well be responsible for a substantial proportion of the long-term mortalit...
متن کاملWithdrawal of Immunosuppression in Pediatric Liver Transplant Recipients in Korea
PURPOSE We identified pediatric liver transplant recipients with successful withdrawal of immunosuppression who developed tolerance in Korea. MATERIALS AND METHODS Among 105 pediatric patients who received liver transplantation and were treated with tacrolimus-based immunosuppressive regimens, we selected five (4.8%) patients who had very low tacrolimus trough levels. Four of them were noncom...
متن کاملLiver transplantation for hepatitis C virus related liver disease.
Liver transplantation is a useful treatment for end stage liver disease of all aetiologies but recurrent disease presents an ongoing challenge, particularly for hepatitis C virus (HCV) where recurrence is almost universal. Immunosuppression is needed for all patients after transplantation and should be tailored to the individual patient, with particular problems being noted for those with HCV. ...
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The outcome of a transplanted organ depends frequently upon the occurrence of allograft rejection and infection episodes. These 2 events are closely related. On one side, immunosuppressive therapy is required to avoid allograft rejection, but on the other side this therapy facilitates the occurrence of infections (1). A better understanding of allograft rejection mechanisms along with new immun...
متن کاملPosttransplant metabolic syndrome in the withdrawal of immunosuppression in Pediatric Liver Transplant Recipients (WISP-R) pilot trial.
Posttransplant metabolic syndrome (PTMS)-obesity, hypertension, elevated triglycerides, low HDL and glucose intolerance-is a major contributor to morbidity after adult liver transplant. This analysis of the Withdrawal of Immunosuppression in Pediatric Liver Transplant Recipients (WISP-R) pilot trial is the first prospective study of PTMS after pediatric liver transplant. Twenty children were en...
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